Flow carbonylation of sterically hindered ortho-subsituted iodoarenes
Carl J. Mallia1, Gary C. Walter2, Ian R. Baxendale1
- 1 Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom
- 2 Syngenta CP R&D Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United KingdomRead the publication that featured this abstract
The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust :
- Easy to use :
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.