Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method
- Y. Fanga
- G. K. Tranmer*ab
- * Corresponding author
- a College of Pharmacy, Faculty of Health Science, University of Manitoba, Winnipeg, Canada
- b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, CanadaRead the publication that featured this abstract
A single-step continuous flow method has been developed that gives expedited access to complex heterocycles via an intramolecular photochemical cyclization. Herein we report the first examples of the photochemically-induced generation of thieno[3,2-c]quinolin-4(5H)-ones, 16 examples, and benzo[h]-1,6-naphthyridin-5(6H)-ones, 6 examples. Overall, the continuous flow method provides access to complex heterocycles in two steps from commercially available starting materials in good yields and with greater atom efficiency than traditional batch reactions.
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