Enzyme-electrochemical continuous flow cascades synthesis of substituted benzimidazoles

Added on:
30 Mar, 2021

A green and efficient method for the synthesis of substituted benzimidazoles has been developed in a two-step continuous flow system. Enzyme-electrochemical cascade reactions between aromatic alcohols with o-phenylenediamines is reported. The reaction was performed under mild reaction conditions with air as “green” oxidant and oxidase as biocatalyst. Alcohols oxidation and substituted benzimidazoles formation were integrated into a single operation which is usually accomplished separately. The scale up experiment was completed successfully in continuous flow system which offers an industrially relevant, practical and efficient method.

  • Ting-Ting Shia,b
  • Shu-Zhan Wanga
  • Zhao Yangc
  • Yilin Wanga
  • Chengkou Liua
  • Wei He*a
  • Zheng Fang*a,d
  • Kai Guoad
  • aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
  • bDepartment of Chemistry, Bengbu Medical College, 233030, P. R. China.
  • cSchool of Engineering, China Pharmaceutical University, No.639 Longmian Avenue, Nanjing 211198, China
  • dState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
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