Enzyme-electrochemical continuous flow cascades synthesis of substituted benzimidazoles
- Ting-Ting Shia,b
- Shu-Zhan Wanga
- Zhao Yangc
- Yilin Wanga
- Chengkou Liua
- Wei He*a
- Zheng Fang*a,d
- Kai Guoad
- aCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
- bDepartment of Chemistry, Bengbu Medical College, 233030, P. R. China.
- cSchool of Engineering, China Pharmaceutical University, No.639 Longmian Avenue, Nanjing 211198, China
- dState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
Read the publication that featured this abstractA green and efficient method for the synthesis of substituted benzimidazoles has been developed in a two-step continuous flow system. Enzyme-electrochemical cascade reactions between aromatic alcohols with o-phenylenediamines is reported. The reaction was performed under mild reaction conditions with air as “green” oxidant and oxidase as biocatalyst. Alcohols oxidation and substituted benzimidazoles formation were integrated into a single operation which is usually accomplished separately. The scale up experiment was completed successfully in continuous flow system which offers an industrially relevant, practical and efficient method.
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