An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid

    • Kana kunihiro1
    • Laurence Dumais2
    • Guillaume Lafitte2
    • Emeric Varvier2
    • Loïc Tomas2
    • Craig Harris2
    • 1 Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France
    • 2 Nestlé Skin Health, Galderma R&D, France

    Organoboron compounds are valuable molecules of increasing interest in organic synthesis, catalysis, biology and medicine. Among them, benzoxaboroles emerged as promising building blocks for numerous research programs. In this letter, we communicate the development of new conditions for the one‐pot benzoxaborole synthesis by SiliaCat DPP‐Pd catalysis using diboronic acid as the boron source. This low cost and sustainable strategy permitted the preparation of a useful range of benzoxaborole building blocks. Finally, the transformation was extended to a continuous flow process using our Vapourtec system.

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