Continuous slurry plug flow Fe/ppm Pd nanoparticle-catalyzed Suzuki–Miyaura couplings in water utilizing novel solid handling equipment

    • Alex B. Wooda
    • Scott Plummerb
    • Richard I. Robinsonb
    • Marie Smithc
    • Jim Changc
    • Fabrice Galloud
    • Bruce H. Lipshutza
    • aDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA
    • bGlobal Discovery Chemistry – Chemistry Technology Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    • cGenomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Dr., San Diego, CA 92121, USA
    • dNovartis Pharma AH, CH-4057 Basel, Switzerland

    Herein are reported initial efforts to develop a generally accessible flow process, applying a heterogenous nanocatalyst to aqueous micelle-enabled Suzuki–Miyaura coupling reactions. Also disclosed is a new engineering solution (i.e., a self-draining back pressure regulator), which, when applied, enabled 1.5 hours of continuous operation leading to the production of 20 grams of a pharmaceutical intermediate.

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