Continuous Photoflow Synthesis of Heterohelicenes

Heterohelicenes continue to attract interest for their potential applications as organic chiral materials. To keep up with the demand for novel heterohelicene structures, expedient and scaleable synthetic procedures are required. We report a “Mallory” photocyclization methodology in continuous flow for the synthesis of thia-, oxa-, and azahelicenes. This procedure has been successfully scaled up to 9.8 mmol and can be applied to an iterative modular synthesis.

• Lyon K¹
• Pan C²
• Sathiyalingam S^1,2
• Wu Y²
• Matthews J¹
• Brandt JR¹

•   ¹School of Physical and Chemical Sciences, Queen Mary University of London, 327 Mile End Road, London E1 4NS, U.K.
• ²Department of Chemistry and Molecular Sciences Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London W12 0BZ, U.K.

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