Continuous-Flow Synthesis of Alkyl Zinc Sulfinates for the Direct Photofunctionalization of Heterocycles

• José Luis Nova-Fernández^a,b
• Montaña J. García^a
• Leonardo Mollari^a
• Gustavo Pascual-Coca^b
• Silvia Cabrera^c,d,e
• José Alemána^d,e

• ^aOrganic Chemistry Department, M1, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
• ^bSynthelia Organics Labs, C/ Faraday, 7, Labs 2.05 and 0.03, Parque Científico de Madrid, 28049, Madrid, Spain.
• ^cInorganic Chemistry Department, M7, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
• ^dInstitute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
• ^eCenter for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid.

A sustainable strategy for the alkylation of heterocycles is presented. The protocol relies on the in-situ generation and further in-line use of alkyl zinc sulfinates through a continuous-flow system. The environmentally friendly character of the protocol is assured by the use of a green solvent mixture, the presence of a metal free oxidant and low waste generation.

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