Continuous-flow synthesis and derivatization of aziridines through palladium-catalyzed C(sp3)−H activation
Jacek Zakrzewski1, Adam P. Smalley2, Dr. Mikhail A. Kabeshov2, Prof. Matthew J. Gaunt2, Prof. Alexei A. Lapkin1
- 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
- 2 Chemistry Department, University of Cambridge, Cambridge, UKRead the publication that featured this abstract
A continuous-flow synthesis of aziridines by palla-dium-catalyzed C(sp3)H activation is described. The newflow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphaticamines through a consecutive process. A predictive mechanis-tic model was developed and used to design the CH activationflow process and illustrates an approach towards first-princi-ples design based on novel catalytic reactions.
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