Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

Brenda Pijper¹, Jesus Alcázar¹, Gabriela Oksdath-Mansilla², Fabricio Román Bisogno²

• ¹Discovery Chemistry, Janssen, Pharmaceutical Companies of Johnson and Johnson, Janssen-Cilag, S.A., Calle Río Jarama 75A, 45007 Toledo, Spain
• ²INFIQC-CONICET-UNC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina

In this Activity article, Brenda Pijper (Horizon 2020 PhotoReAct early-stage researcher in the Chemical Technologies group at Janssen, the Pharmaceutical Companies of Johnson & Johnson) and Jesus Alcázar (head of the Chemical Technologies group at Janssen) and Gabriela Oksdath-Mansilla and Fabricio R. Bisogno (both professors at the Universidad Nacional de Córdoba and researchers at the National Scientific and Technical Research Council of Argentina [CONICET]) discuss the current state of continuous-flow photochemistry in drug discovery and its future as an automated platform integrated with closed-loop artificial intelligence and machine learning (AI/ML) approaches.

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