Continuous Flow Generation of Highly Reactive Organometallic Intermediates: A Recent Update

    • Mauro Spennacchio
    • Philipp Natho
    • Michael Andresini
    • Marco Colella
    • Department of Pharmacy-Drug Sciences, University of Bari “A. Moro”, Via E. Orabona 4, 70125, Bari, Italy

    Reactive organometallic intermediates present a distinct opportunity for the creation of novel carbon-carbon and carbon-heteroatom bonds. Whereas their utility in synthesis is well-established, the thermal sensitivity of these species often imposes the requirement for stringent reaction conditions, including strict control of reaction temperatures, concentrations, and use of additives. Moreover, their strong reactivity can pose challenges in achieving the desired selectivity. Since pioneering works in the 2000s, the advent of flow microreactor technology has revolutionized this field, expanding the possibilities of reactive organometallic intermediates within synthetic chemistry. In this review, we provide an overview of the recent advancements in this dynamic area, focusing on breakthroughs that have emerged within the past four years.

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