Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata
- Matteo Planchestainera
- Martina Letizia Contenteab
- Jennifer Cassidya
- Francesco Molinarib
- Lucia Tamborini*c
- Francesca Paradisi*ad
- * Corresponding authors
- a UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
- b Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
- c Department of Pharmaceutical Sciences (DISFARM), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
- d School of Chemistry, University of Nottingham, University Park, Nottingham, UKRead the publication that featured this abstract
The continuous flow synthesis of a series of amines was successfully achieved by exploiting the enhanced stability and broad substrate scope of an immobilised transaminase from Halomonas elongata (HEWT). A series of substrates were tested in flow reactors and transformed into the corresponding amines in good to excellent yields. The process was implemented with an integrated in-line purification step for the recovery of the pure amines.
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