Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene
- Dimitrije Djukanovica
- Benjamin Heinza
- Dr. Francesca Mandrellib
- Dr. Serena Mostardab
- Dr. Paolo Filipponib
- Dr. Benjamin Martinb
- Prof. Dr. Paul Knochela
- aDepartment Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, Haus F, 81377 Munich, Germany
- bNovartis Pharma AG, Chemical Development Fabrikstraße, 4002 Basel, SwitzerlandRead the publication that featured this abstract
N,N-Dimethylamides for continuous flow acylations: A new acylation of (hetero)aryllithiums with polyfunctional and enolizable N,N-dimethylamides in toluene in continuous flow was reported. The required lithium species was prepared at 25 °C from (hetero)aryl bromides and sec-BuLi in toluene. Additionally, a new telescoped procedure, using tetramethylurea as C1-building block, was described providing highly functionalized unsymmetrical ketones.
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