Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates

• Saurabh Anand
• Sandhya Mardhekar
• Rakesh Raigawali
• Nirmala Mohanta
• Prashant Jain
• Chethan D. Shanthamurthy
• Boopathy Gnanaprakasam*
• Raghavendra Kikkeri*

• Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India

We report for the first time a continuous-flow strategy to execute O-sulfation modification of heparan sulfate (HS) oligosaccharides. A systematic investigation of the influence of the flow parameters on the installation of the sulfate group on glucosamine monosaccharide can aid the development of a comprehensive, quick, and reliable strategy for O-sulfation of HS oligosaccharide precursors. Deprotection of the sulfated heparin intermediates led to the development of a comprehensive biologically inspired oligosaccharide library to understand the crucial structure–function relationship of HS.

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