Continuous Flow α-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis
- Juan A. Vega
- José Manuel Alonso
- Gabriela Méndez
- Myriam Ciordia
- Francisca Delgado
- Andrés A. Trabanco
- Neuroscience Medicinal Chemistry, Janssen Research & Development, Jarama 75A, 45007 Toledo, SpainRead the publication that featured this abstract
The first direct α-arylation of aldehyde-derived N,N-dialkylhydrazones with electron deficient aryl and heteroaryl cyanides under visible-light photoredox catalysis has been developed. Structurally complex α,α′-diaryl-N,N-cycloalkylhydrazones were obtained in moderate yields by repetition of the direct arylation protocol. A continuous-flow procedure for the preparation of α-aryl-N,N-dialkylhydrazones on a multigram scale has also been established.
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