Continuous‐Flow Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications

    Dr Mohamed Elsherbini, Bethan Winterson, Haifa Alharbi, Ana A. Folgueiras-Amador, Clina Gnot, and Thomas Wirth

    • School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT UK

    An efficient and reliable electrochemical generator of hypervalent iodine reagents has been developed. In the anodic oxidation of iodoarenes to hypervalent iodine reagents under flow conditions, the use of electricity replaces hazardous and costly chemical oxidants. Unstable hypervalent iodine reagents can be prepared easily and coupled with different substrates to achieve oxidative transformations in high yields. The unstable, electrochemically generated reagents can also easily be transformed into classic bench‐stable hypervalent iodine reagents through ligand exchange. The combination of electrochemical and flow‐chemistry advantages largely improves the ecological footprint of the overall process compared to conventional approaches.

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