Consecutive photochemical reactions enabled by a dual flow reactor coil strategy

• Ruairi Crawford^a
• Mara Di Filippo^a
• Duncan Guthrie^b
• Marcus Baumann^a

• ^aSchool of Chemistry, Science Centre South, University College Dublin, D04 N2E2, Dublin, Ireland
• ^bVapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk, IP28 6TS, UKM

The application of a dual reactor coil for consecutive photochemical reactions is presented in continuous flow mode. This strategy enables for the first time the use of a single LED-based light source to perform two distinct photochemical reactions in an uninterrupted fashion. This approach is demonstrated for the telescoped synthesis and functionalisation of drug-like quinolines and compared to alternatives exploiting two photochemical reactor set-ups operated in sequence. The presented strategy enables the intensified exploitation of photochemical reactions in modern synthesis.

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