Cobalt photocatalysed carbonylation reactions in continuous flow

A cobalt photocatalysed carbonylation reaction has been developed and applied in continuous flow. Dicobalt octacarbonyl, [Co2(CO)8], serves both as a catalyst and as a carbon monoxide surrogate for the synthesis of amides and esters. The process is technically straightforward, has been applied to pharamceutical derviatives and demonstrated on multi-gram scale.

Equipment used in this paper: UV-150 Photochemical Reactor

• Martínez-Aguirre M¹
• Bailey R¹
• Schaefer B²
• Crimmin M¹
• Miller P¹

•   ¹Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London, W12 OBZ, UK.
• ²BASF, Ludwigshafen am Rhein, Rhineland-Palatinate, Germany.

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