Catalytic macrocyclization strategies using continuous flow: formal total synthesis of ivorenolide A

• Mylène de Léséleuc, Eric Godin, Shawn Parisien-Collette, Alexandre Levesque, and Shawn K. Collins

• University of Montréal, Department of Chemistry, Montréal, Canada

A formal total synthesis of ivorenolide A has been accomplished employing a Z-selective olefin cross metathesis and a macrocyclic Glaser-Hay coupling as key steps. The macrocyclization protocol employed a phase separation/continuous flow manifold whose advantages include catalysis, fast reaction times, high concentrations and facile scale-up.

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