Automated multistep synthesis of 2-pyrazolines in continuous flow

The synthesis of 2-pyrazolines from aldehydes via cycloaddition of unstabilised diazo species and alkenes is reported, including automated library generation and graphical interface for reaction control.

• Richardo Labes
• Julio C. Pastre
• Richard J. Ingham
• Claudio Battilocchio
• Henrique M. Marçon
• Mariana C. F. C. B. Damião
• Duc N. Tran
• Steven V. Ley

• Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

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