Automated multistep synthesis of 2-pyrazolines in continuous flow

    • Richardo Labes
    • Julio C. Pastre
    • Richard J. Ingham
    • Claudio Battilocchio
    • Henrique M. Marçon
    • Mariana C. F. C. B. Damião
    • Duc N. Tran
    • Steven V. Ley
    • Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

    The synthesis of 2-pyrazolines from aldehydes via cycloaddition of unstabilised diazo species and alkenes is reported, including automated library generation and graphical interface for reaction control.

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