Application Note 31: Process Scale Uncatalysed Amination of 2-Chloropyridine (SNAr) under Solvent Free (Neat, 10.6M) Conditions

This application note illustrates the use of the Vapourtec R-Series system to run reactions under solvent free (neat) conditions. It expands the work previously highlighted in Application note 29 in which a novel stratagem for throughput of material was demonstrated using a bench top system. By harnessing the higher temperatures and pressures available on the Vapourtec R-Series and again running the reaction solvent free it is possible to perform direct uncatalyzed amination of 2-chloropyridine on potentially larger scales than previously thoughtⁱ.