Application Note 28: Continuous O-Methylation of Carboxylic Acids with Trimethylsilyldiazomethane


    This application note illustrates the use of the Vapourtec R-Series system to pump highly reactive, hazardous reagents in a safe and stable continuous reaction. Here we describe the continuous O-methylation of a carboxylic group with trimethylsilyldiazomethane (TMSCHN 2 ) pumping directly through the R-series acid resistant pump heads.

    Join the Vapourtec Knowledge Base to access this Application note

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us