Continuous O-Methylation of Carboxylic Acids with Trimethylsilyldiazomethane

This application note illustrates the use of the Vapourtec R-Series system to pump highly reactive, hazardous reagents in a safe and stable continuous reaction. Here we describe the continuous O-methylation of a carboxylic group with trimethylsilyldiazomethane (TMSCHN 2 ) pumping directly through the R-series acid resistant pump heads.

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