Application Note 2 – Optimisation of Step 1 in the Synthesis of Linezolid using a ‘Dual-Core™’ Tubing Reactor


    This Application Note illustrates how the smaller volume tubing reactor (810 mL) within a Dual-CoreTM element was used to determine optimal flow-through conditions suitable for the scale-up synthesis of the intermediate 3 required for the preparation of UpJohn’s oxazolidinone antibiotic linezolid (Zyvox®).

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