Array Synthesis using Loop Injection and a Tubing Reactor Combined with a Scavenger Column

This Application Note illustrates how the R-2⁺ pump/injector and R-4 flow reactor modules can be used in combination with a tubing reactor and a PACT scavenger column to perform sequential array synthesis employing simultaneous loop injection. Excess starting material 2{n} is used to drive the SN_Ar reaction with the aryl fluoride 1 to completion by incubation in the tubing reactor. The remaining amine is then scavenged prior to collection of the product 3{n}.

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