Telephone +44(0)1284 728659
Email [email protected]
This Application Note illustrates how the R-2+ pump/injector and R-4 flow reactor modules can be used in combination with a tubing reactor and a PACT scavenger column to perform sequential array synthesis employing simultaneous loop injection. Excess starting material 2{n} is used to drive the SNAr reaction with the aryl fluoride 1 to completion by incubation in the tubing reactor. The remaining amine is then scavenged prior to collection of the product 3{n}.