A simple one-pot oxidation protocol for the synthesis of dehydrohedione from Hedione
- James S. Sharleya, Guido Gambacortaa, Ana María Collado Pérezb, Estela Espinos Ferrib, Amadeo Fernandez Mirandab, Isabelle Fernández Fernándezb, Jorge Sanchez Quesadab, Ian R.Baxendalea
- aDepartment of Chemistry, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
- bInternational Flavours & Fragrances Inc., Avda Felipe Klein 2, 12580, Benicarló, Castellón, Spain
Read the publication that featured this abstractA new method for the oxidiation of Hedione 1 to dehydrohedione 2, a high value intermediate in the flavour and fragrance industry, has developed based upon one pot α-chlorination-elimination sequence which can be readily scaled. The spontaneous elimination of the α-chloro in methanol was unprecedented and has allowed for the oxidation, typically performed in multiple steps/reactions, to be carried out as a one-pot protocol. A continuous flow process for performing the reaction utilising sulfuryl chloride has also demonstrated allowing for steady, safe evolution of SO2 gas during the reaction.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series

The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series

The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.