A practical method for continuous production of sp3-rich compounds from (hetero)aryl halides and redox-active esters

• Eiichi Watanabe^a
• Yiding Chen^b
• Oliver May^b
• Steven V. Ley^*b

• ^aNew Path Molecular Ltd. Building 580, Babraham Research Campus, Cambridge (UK)
• ^bDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)

A practically useful coupling reaction between aromatic halides and redox‐active esters was realized via nickel catalysis through the use of packed zinc bed column in continuous flow. Multiple reuse of the column showed a negligible decrease in efficiency, affording high space/time yields. A wide range of substrates, including a number of heteroaryl halides and polyfunctional materials were coupled in generally good yields. Longer‐time and larger‐scale experiments further demonstrates the robustness of the system.

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