γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket

• Lucia Tamborini^a
• Veronica Nicosia^a
• Paola Conti^a
• Federica Dall'Oglio^a
• Carlo De Micheli^a
• Birgitte Nielsen^b
• Anders A. Jensen^b
• Darryl S. Pickering^b
• Andrea Pinto^a

• ^a Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
• ^b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark

γ-Glutamyl-dipeptides, built by condensing the distal carboxylate of l-Glu (or d-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereo-electronic properties of iGluRs, searching for subtype-selective ligands.

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