γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket
- Lucia Tamborinia
- Veronica Nicosiaa
- Paola Contia
- Federica Dall'Oglioa
- Carlo De Michelia
- Birgitte Nielsenb
- Anders A. Jensenb
- Darryl S. Pickeringb
- Andrea Pintoa
- a Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
- b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark
Read the publication that featured this abstractγ-Glutamyl-dipeptides, built by condensing the distal carboxylate of l-Glu (or d-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereo-electronic properties of iGluRs, searching for subtype-selective ligands.
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