Direct Oxime Etherification of Inert C (Sp3)-H Via Photo-Driven Hat in Batch or Continuous Flow Mode

We report an efficient photocatalytic strategy for direct oxime etherification of unactivated C(sp3)-H bonds through hy-drogen atom transfer (HAT) activation, employing low-loading FeCl3 as catalyst under blue light irradiation. This meth-odology demonstrates a broad substrates scope with excellent functional group tolerance, including cycloalkanes, ethers, amides, sulfonamides, phosphoramides, and ketones. Furthermore, the reaction system exhibits remarkable scalability through continuous-flow photoreactor, achieving practical gram-scale production of pharmaceutically relevant oxime ether derivatives with improved yields.

• Pan, Y
• Qiao, K
• Shao, B
• Du, X
• Jiang, W
• Shi, 

• Dalian University of Technology

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