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In this personal perspective, hybrid-enabling technologies are referred to as the integration of multiple methodologies, platforms, and technologies in organic synthesis to allow for more efficient, selective, and sustainable chemical reactions. These technologies are often combined with traditional or classical synthetic methods to enable innovative synthetic approaches aimed at addressing the challenges associated with conventional organic synthesis. Emphasis is placed on the utilization of enabling methods, with flow chemistry being positioned at the forefront, to facilitate more sustainable production of biomolecules, agrochemicals, and pharmaceuticals.