Two-step continuous flow-driven synthesis of 1,1-cyclopropane aminoketones

The continuous flow telescoped synthesis of 1,1-cyclopropane aminoketones was achieved by optimizing the photocyclization of 1,2-diketones to 2-hydroxycylobutanones (HCBs) and their reaction with aryl- and alkylamines, via tandem condensation C4-C3-ring contraction reaction. With the achieved operational conditions, we were able to obtain a library of cyclopropylamines with good chemical yields, high productivity, and short residence times.

• Velichko, V
• Moi, D
• Soddu, F
• Scipione, R
• Podda, E
• Luridiana, A
• Cambie, D
• Secci, F
• Cabua, MC

• Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Complesso Universitario di Monserrato, 09042, Monserrato (Cagliari), Italy

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