Gas-liquid tubular continuous-flow Pd-catalysed aminocarbonylation process for scalable synthesis of carboxamides

We report an efficient continuous flow process, integrating a custom-designed gas input control system coupled with a tubular reactor, for Pd-catalysed aminocarbonylation, which leads to the multigram synthesis of biologically relevant carboxamides.

• Rodrigues, F
• Masliy, V
• Hryhoryev, Y
• Dias, L
• Carrilho, R
• Calvete, M
• Takács, A
• Mikle, G
• Kollár, L
• Pereira, M

• Coimbra Chemistry Centre, Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal

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