Date: 11 April 2024 | Category: News
Broadening flow chemistry horizons over the past decade
Vapourtec’s E-Series flow chemistry system has reached the notable landmark of 300 installations around the globe.
Firmly established over the last ten years as the leading entry-level flow chemistry system, the E-Series has also been pivotal in many key research breakthroughs, appearing in over 250 peer-reviewed publications.
The most notable citations include “Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z) Tamoxifen” (P. R. D. Murray, D. L. Browne, J. C. Pastre, C. Butters, D. Guthrie, S. V. Ley, Org. Proc. Res. Dev. 2013, 17, 1192−1208) [1] and “C(sp3 )–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flow” (G. Laudadio, Y. Deng, K. van der Wal, D. Ravelli, M. Nuño, M. Fagnoni, D. Guthrie, Y. Sun, T. Noël, Science 2020, 369, 92-96) [2].
The E-Series is currently in use within 20 nations and is utilised by all the major international pharmaceutical companies.
Looking back over the past decade of the E-Series, Vapourtec founder and MD Duncan Guthrie commented: “The E-Series has surpassed our expectations in terms of its impact within academia and industry and has introduced the potential of a continuous process approach to thousands of chemists around the globe. It’s also played a key role in many flow chemistry research breakthroughs since its launch ten years ago.
“It works seamlessly with our array of reactors and other technologies to open novel chemical space and broaden the horizons of flow chemistry.
“New software will be launched later this year to further enhance the capabilities of the E-Series system.
“From our first customer at Gilead, Alberta to our latest 300th installation for Dr Nick Tomkinson at the University of Strathclyde, this system has simplified research in and the teaching of flow chemistry with feedback being overwhelmingly positive,” added Duncan.
E-Series system owner Dr Filipe Vilela (VilelaLAB, Heriot-Watt University) commented: “The Vapourtec E-Series flow chemistry system is an invaluable asset in our lab, empowering diverse research endeavours with its versatility, ease of operation, and robust performance. Its broad range of reactors and precise control over reaction parameters have enabled us to explore new avenues in chemistry with confidence and efficiency. In our lab, its application extends across various domains including polymer chemistry, photochemistry, and advanced synthetic technologies such as continuous purification. With the Vapourtec E-Series, we’ve been able to seamlessly integrate these diverse research areas, accelerating our progress towards innovative solutions and novel discoveries. Moreover, the scientific and technical support from Vapourtec has been instrumental in the development of our research, providing invaluable insights and guidance as we navigate through complex challenges and push the boundaries of scientific exploration.”
It is currently available in four standard configurations: easy-Scholar, easy-Polymer, easy-Medchem, and easy-Photochem with each offering precise control over reaction parameters and a modular design that means each system can be configured to suit specific needs. With pumps able to handle strong acids as well as air and moisture-sensitive reagents and suspensions, these systems can tackle a variety of chemistries.
Duncan concluded: “Robustness and ease of use have helped to establish the E-Series in the marketplace.
“With machine learning and AI playing an ever-growing role, the E-Series will continue to evolve as a cutting-edge tool for flow chemistry. The new software package will provide automated reactions, data logging, and interfaces to other laboratory equipment.
“This will enable telescoped reactions that incorporate E-Series and R-Series pumps, reactors, and third-party laboratory tools for analysis and automation.
“As it enters its second decade, the future is looking bright for the E-Series; a system that has increased the scope and potential of flow chemistry.”
[1] Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z) Tamoxifen (P. R. D. Murray, D. L. Browne, J. C. Pastre, C. Butters, D. Guthrie, S. V. Ley, Org. Proc. Res. Dev. 2013, 17, 1192−1208) https://pubs.acs.org/doi/10.1021/op4001548
[2] C(sp3)–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flow (G. Laudadio, Y. Deng, K. van der Wal, D. Ravelli, M. Nuño, M. Fagnoni, D. Guthrie, Y. Sun, T. Noël, Science 2020, 369, 92-96) https://www.science.org/doi/10.1126/science.abb4688
To find out more about the E-Series, click here
To download a list of all 250 publications citing the E-Series, click here
