Visible Light-Mediated Direct Decarboxylative Giese Amidations without a Photocatalyst─Batch and Flow

Previous light-mediated approaches to the direct decarboxylative Giese amidation reaction relied on the use of costly, nonsustainable photocatalysts and faced challenges in efficient scale-up. We have successfully developed a photocatalyst-free, light-mediated methodology via a pathway that is thought to involve in situ EDA formation. The reaction is applicable in batch as well as under flow conditions, including efficient scale-up to gram scale in flow.

Equipment used in this paper: E-Series Flow Chemistry System

• Nickels S
• Kitcatt D
• Vilela F
• Lee A

•   Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, U.K.
• EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, U.K.

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