Application Note 68: Photocatalytic Synthesis of γ-Lactams and α-Tertiary Amine Derivatives in Continuous Flow

    Application-note-68-scheme

    We report a simple and direct solution to the synthesis of γ-lactams 4 (incl. azaspirocycles) and α-tertiary amine derivatives 5. Using a cheap organic photocatalyst (4CzIPN) in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, the α-C–H alkylation of aliphatic primary amines 1 with acrylate Michael acceptors 2 can be affected (Scheme 1).1

    Join the Vapourtec Knowledge Base to access this Application note

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote