Continuous Distillation for Drug Substance Manufacturing

Continuous distillation is widely used in the commodity and petrochemical industry to purify fine chemicals on massive industrial scales; however, this key separation strategy is largely unused within the pharmaceutical industry. This article investigates the development of a pilot-scale continuous distillation system for in-line removal of an excess amine reactant (i.e., tert-butylamine) when incorporated within an advanced manufacturing technology (AMT) for continuous drug substance production.

Equipment used in this paper: SF-10 Laboratory Pump

• Penzer K
• Gregory D
• Turnage J
• Thieken C
• Kohn S
• Ferri J

•   Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 West Main St., Richmond, VA, 23284, USA

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