Application of Direct Inject Liquid Chromatography (DILC) as Real-Time Process Analytical Technology for Flow Reactions

Herein, we report advanced applications of the direct inject liquid chromatography (DILC) system as a powerful automated tool for monitoring reaction conversions in flow reactions for the first time. The DILC system has proven highly effective in flow reactions by facilitating reaction optimization, enhancing sustainability, and minimizing human intervention. Our successful demonstration of DILC in flow mode paves the way for its potential application as an in-process control (IPC) tool to monitor both homogeneous and heterogeneous batch reactions at manufacturing scale. Building on these achievements, the implementation of DILC in flow mode not only streamlines process optimization and analytical workflows but also lays the groundwork for future advancements in automated IPC technologies.

• Yining Ji¹
• Umme Ayesa¹
• François Lévesque² Yangzhong Qin¹

•   ¹Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States
• ²Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

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