Novel Application of Direct Inject Liquid Chromatography (DILCTM) as Real-time Process Analytical Technology for Flow Reactions

We report advanced applications of the DILCTM system as a powerful automated tool for monitoring reaction conversions in flow processes for the first time. By applying the DILCTM system to a photocatalytic flow reaction, we systematically mapped the reaction conversions across various residence times and temperatures. The DILCTM system has demonstrated significant effectiveness in flow reactions by facilitating reaction optimization, enhancing sustainability, and minimizing human intervention. Furthermore, the DILCTM has proven to be an excellent online tool for calibrating spectroscopic data. This innovative methodology not only streamlines analytical workflows but also lays the groundwork for future advancements in automated in-process control (IPC) technologies.

• Qin, Y
• Ayesa, U
• Lévesque, F
• Ji, Y

• Merck & Co., Inc

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