Cost-efficient temperature mediation of DPMS synthesis in flow using continuous flow chemistry

Added on:
25 Jun, 2024

An efficient synthesis of diphenylmethylsilanol (DPMS) utilizing continuous flow chemistry was performed using a coil reactor and an ice bath. The inclusion of careful temperature control minimized the exothermic production of an unwanted dimer. Yields of up to 88% were obtained and dimer formation as low as 2.2% was confirmed by NMR. This material will be used in the formulation to make SX358 and its physical and chemical characteristics will be determined using DSC, DMA, TMA, compression set testing and FTIR.

  • Aloisi, M
  • Luteran, E
  • Harper, J
  • Peterson, P
  • Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
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