Metal-free [2+2]-photocycloaddition of unactivated alkenes enabled by continuous flow processing

A continuous flow approach for generating bicyclic cyclobutanes from unactivated alkenes in a metal-free manner, inspired by the Kochi–Salomon reaction, is reported. A filtered Hg-lamp, in combination with a simple flow setup and acetone as a UV light-absorbing co-solvent, was found to be crucial for this method. Attractive features for further exploitation are thereby showcased.

• O'Hanlon, D
• Davin, S
• Glennon, B
• Baumann, M

• APC Ltd, Cherrywood Business Park, Loughlinstown, Co., Dublin, D18 DH50, Ireland

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