Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles
Anne-Catherine Bédard, Jeffrey Santandrea, Shawn K. Collins
- Department of Chemistry and Centre for Green Chemistry and Catalysis, University of Montreal
Read the publication that featured this abstractThe continuous-flow synthesis of a series of 11- to 26-membered macrocycles via copper-catalyzed azide-alkyne cycloaddition is reported. The approach employs homogeneous catalysis to promote formation of triazole-containing macrocycles in good to excellent yields (65–90%) at relatively high concentration (30–50 mM) using a phase separation strategy.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series
![R-Series-home-page apourtec-R-Series-flow-chemistry-system](https://www.vapourtec.com/wp-content/uploads/2014/08/R-Series-home-page-1-300x393.jpg)
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series
![Vapourtec_E-series-medcem Vapourtec E-Series medchem flow chemistry system](https://www.vapourtec.com/wp-content/uploads/2021/03/Vapourtec_E-series-medcem-300x377.jpg)
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.