Lithium aluminum hydride in flow: overcoming exotherms, solids, and gas evolution en route to chemoselective reductions

    Aliakbar Mohammadzadeha, Sepideh Sharifa, Volodymyr Semeniuchenkoa, Norman Townsendb, Andrew D. Corbettb, Michael G. Organa

    • aFlow Chemistry Core Facility, Centre for Catalysis Research and Innovation (CCRI)Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada
    • bToronto Research Chemicals, a Subsidiary of LGC, 20 Martin Ross Avenue, Toronto, ON, M3J 2K8, Canada

    A reactor has been designed specifically to conduct lithium aluminum hydride reductions in flow. The reactor readily accommodates strong hydrogen gas evolution and allows strict control over the combination of starting material and reductant, the reaction itself, and quenching, all of which are conducted within the confines of the reactor leading to a safe process.

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