Iron-catalyzed synthesis of pyridines from α,β-unsaturated ketoxime acetates and N-acetyl enamides

Added on:
5 Nov, 2021

A new method of FeCl2-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.

  • Gaochen Xu1
  • Huan Yan1
  • Sai Zhang1
  • Qinghuan Wu1
  • Jindian Duan1
  • Kai Guo1
  • 1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
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