Iron-catalyzed synthesis of pyridines from α,β-unsaturated ketoxime acetates and N-acetyl enamides
- Gaochen Xu1
- Huan Yan1
- Sai Zhang1
- Qinghuan Wu1
- Jindian Duan1
- Kai Guo1
- 1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, ChinaRead the publication that featured this abstract
A new method of FeCl2-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.
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