Continuous-flow Fe-zeolite-catalyzed temperature-directed synthesis of bioactive tetraketones and xanthenes using epoxides and cyclic-1,3-diketones via a Meinwald rearrangement
- Shankhajit Mondala
- Akanksha M. Pandeya
- Boopathy Gnanaprakasama
- aDepartment of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India
Read the publication that featured this abstractAn environmentally benign approach for bioactive tetraketones using epoxides and cyclic-1,3-diketones in the presence of Fe-zeolite as a catalyst via a Meinwald rearrangement was developed under batch and continuous flow modes. Further increasing the temperature to 180 °C, these tetraketones underwent a cyclization reaction in the presence of catalytic Fe-zeolite to afford xanthene derivatives. Moreover, this Fe-zeolite catalyst was also used for the reaction of aldehyde and cyclic 1,3-diketone, affording the tetraketone in a high yield. Advantageously, the present approach enables gram-scale synthesis in batches as well as in continuous flow. This approach can sustainably generate many bioactive tetraketones and xanthenes as it does not produce any waste. The Fe-zeolite used in this process is easy to synthesize in the multigram scale, inexpensive, easy to recover, and recyclable.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series

The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series

The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.