Continuous flow polymer synthesis

    There is growing interest in various “Living Free Radical Polymer synthesis” techniques (in which supply of reagents can be used to control the extent or rate of the reaction), as these techniques give far more control over the size (and topology) of the molecules formed.

    There are various Living Polymer synthesis techniques, including
    • Reversible Addition Fragmentation Chain Transfer (RAFT)
    • Atom transfer radical polymer synthesis(ATRP)
    • Nitroxide-mediated polymer synthesis (NMP)

    Continuous processing offers a way to carry out these processes with great repeatability and control. With inline degassing and long residence time stainless steel reactors, processes that are very oxygen sensitive can be carried out.

    polymerisation

    Examples of published literature for Continuous flow polymer synthesis

    Direct valorisation of waste cocoa butter triglycerides via catalytic epoxidation, ring-opening and polymerisation

    Dorota D Plazaa, Vinzent Strobelb, Parminder Kaur KS Heerb, Andrew B Sellarsd, Seng-Soi Hoongd, Andrew J Clarkd, Alexei A Lapkinb

    • a School of Engineering, University of Warwick, Coventry, UK
    • b Department of Chemical Engineering and Biotechnology, University of Cambridge, UK
    • c Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
    • d Department of Chemistry, University of Warwick, Coventry, UK
    View abstract

    Preparation of Forced Gradient Copolymers Using Tube-in-Tube Continuous Flow Reactors

    Simon Saubern, Xuan Nguyen, Van Nguyen, James Gardiner, John Tsanaktsidis, John Chiefari

    • CSIRO Manufacturing, Clayton, VIC, Australia
    View abstract

    γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket

    Lucia Tamborinia, Veronica Nicosiaa, Paola Contia, Federica Dall'Oglioa, Carlo De Michelia, Birgitte Nielsenb, Anders A. Jensenb, Darryl S. Pickeringb, Andrea Pintoa

    • a Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    • b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark
    View abstract

    Triphenylphosphine-grafted, RAFT-synthesised, porous monoliths as catalysts for Michael addition in flow synthesis

    Kristine J. Barlowa, Victor Bernabeua, Xiaojuan Haoa, Timothy C. Hughesa, Oliver E. Hutta, Anastasios Polyzosa,b, Kathleen A. Turnera, Graeme Moada

    • a CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia
    • b University of Melbourne, School of Chemistry, Parkville, Victoria 3010, Australia
    View abstract

    Photoactive and metal-free polyamide-based polymers for water and wastewater treatment under visible light irradiation

    Junjie Shena, Roman Steinbacha, John Tobina, Mayumi Mouro Nakataa, Matthew Bowerb, Martin McCoustraa, Helen Bridlea, Valeria Arrighia, Filipe Vilelaa

    • a School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom
    • b Drinking Water Quality Regulator for Scotland, Edinburgh, EH6 6WW, United Kingdom
    View abstract

    Continuous flow photo-initiated RAFT polymerisation using a tubular photochemical reactor

    James Gardiner a, Christian H. Hornung a, John Tsanaktsidis a, Duncan Guthrie b

    • a CSIRO Manufacturing, Bag 10, Clayton South, Victoria 3169, Australia
    • b Vapourtec Ltd, Park Farm Business Centre, Bury St Edmunds IP28 6TS, United Kingdom
    View abstract

    Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers

    CH Hornung, A Postma, S Saubern, J Chiefari

    • CSIRO Materials Science and Engineering, Victoria, Australia
    View abstract

    Porous, functional, poly(styrene-co-divinylbenzene) monoliths by RAFT polymerization

    Kristine J. Barlow (née Tan), Xiaojuan Hao, Timothy C. Hughes, Oliver E. Hutt, Anastasios Polyzos, Kathleen A. Turner, Graeme Moad

    • Commonwealth Scientific and Industrial Research Organisation (CSIRO), Materials Science & Engineering, Australia
    View abstract

    Controlled synthesis of poly(3-hexylthiophene) in continuous flow

    Helga Seyler, Jegadesan Subbiah, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong*

    • School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
    • *Corresponding author
    View abstract

    Synthesis of RAFT Block Copolymers in a Multi-Stage Continuous Flow Process Inside a Tubular Reactor

    Christian H. Hornung, Xuan Nguyen, Stella Kyi, John Chiefari, Simon Saubern

    • CSIRO Materials Science & Engineering, Victoria, Australia.
    View abstract

    A Continuous Flow Process for the Radical Induced End Group Removal of RAFT Polymers

    Christian H. Hornung, Almar Postma, Simon Saubern, John Chiefari

    • CSIRO Materials Science & Engineering, Victoria Australia
    View abstract

    Continuous flow synthesis of conjugated polymers

    Helga Seyler, David J. Jones, Andrew B. Holmes, Wallace W. H. Wong

    • Bio21 Institute, University of Melbourne, Australia
    View abstract

    Controlled RAFT Polymerization in a Continuous Flow Microreactor

    Christian H. Hornung, Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

    • CSIRO Materials Science & Engineering, Victoria, Australia
    View abstract

    Application Notes regarding Continuous flow polymer synthesis

    Application Note 5: Heck C-C Coupling using a Monolithic Nanoparticular Pd[0] PACT Reactor Cartridge

    app_note05

    This Application Note illustrates how the R-2 pump/injector and R-4 flow reactor modules can be used in combination with reactor columns to perform Polymer Assisted Continuous flow-Through (PACT) chemistry.

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